Dr. Hao Chen’s research interests are in the areas of electrochemical and optical sensors in microfluidic systems, nitric oxide releasing/generating biomaterials for urinary and dialysis infections and dysfunction, solutions for critical care, stem cell biocompatible systems, micro and macro bio implantable solutions, and technology translation. Hao has contributed in the development of biomedical materials, Raman based SERS technology, nephrostomy balloons, spinal electrode deployment system for pain management, knee and hip alloy implants, polymeric implants, RF cauterizing clamps, micro-electrodes, POC microfluidic hemo related devices (coagulation, cell count, molecular sensors), and some stem cell and embryo research.
Hao founded Biocrede Inc. in 2012, which received 3 NIH SBIR/STTR Phase I awards in 2014, and focuses on medical technologies such as catheters that prevent catheter associated urinary tract infections and tunneled dialysis catheter dysfunction, stem cell technologies, and others. He previously helped spin-off more than 40 patents from Honeywell to form Ativa Med, setup a medical device stent manufacturing site, and acted as director of sales for a high-end medical and pharmaceutical raman quality systems in Latin America.
For the past six years, Hao has worked with researchers at the University of Michigan to develop translational research opportunities. He has in depth knowledge in the design of nephrostomy balloon catheters for Gyrus ACMI (Olympus) to compete against Bard, Boston Scientific, and Cook’s nephrostomy balloon catheters. Hao has managed bio/medical technology development projects for Ethicon Endo Surgery, Dupont, Covidien, Biomet, Medtronic, Abbott, Boston Scientific, Synthes and others via Accellent.
Dr. Chen graduated from the University of Michigan with a PhD degree in Biomedical Engineering. He is also the first student to accomplish PhD degree within two years with a focus on the development of the novel optofluidic lasers at the cellular and tissue level for biomedical and clinical applications. Since 2012, he has already co-authored more than 30 scientific journals/proceedings/patents, while a start-up company is being formed to market the optofluidic biolaser technology in cellular/ tissue imaging based on his pioneer work in PhD. Currently, he is working as a postdoctoral fellow under Professor Xudong Fan's lab. My research mainly lies in two fields, (1) translation medicine research: to design the prototype of Laser-emission microscopy for clinical applications. (2) neural-engineering: novel on-chip biolasing device for optical recording of neural network activities and drug testing.
Dr. Mohamed E.H. ElSayed received his Bachelors and Doctoral degrees in Pharmaceutical Sciences in May 1994 and July 2002 from Cairo University and the University of Maryland in Baltimore, respectively. He was a postdoctoral research fellow at the University of Washington, Department of Bioengineering from November 2002 to August 2006 before joining the University of Michigan in January 2007 where he established the Cellular Engineering & Nano-Therapeutics Laboratory.
Dr. ElSayed’s research program focuses on the development of bio-inspired drug delivery systems that enhance the therapeutic activity of the incorporated drug molecules while eliminating or minimizing their potential side effects. Specifically, Dr. ElSayed investigates the transport mechanism(s) of small molecules, macromolecules, and polymeric drug delivery systems across epithelial and endothelial barriers under normal and pathological conditions and utilizes this knowledge to rationally design and synthesize novel “smart” polymeric carriers that can effectively exploit these transport mechanisms to selectively deliver their therapeutic cargo to the diseased tissues with cellular and sub-cellular accuracy.
Dr. ElSayed is a recipient of the US Department of Defense Idea Award in Prostate Cancer Research, Coulter Foundation Translational Research Partnership in Biomedical Engineering Award, the National Science Foundation-CAREER Award, the Susan G. Komen Breast Cancer Foundation Postdoctoral Fellowship, the US Department of Defense Multidisciplinary Postdoctoral Award in Breast Cancer Research, and the National Cancer Center Postdoctoral Fellowship.
Dr. ElSayed is a member of the Rho-Chi National Pharmacy Honor Society, the Controlled Release Society, the American Association of Pharmaceutical Scientists, and the Biomedical Engineering Society.
Professor Fan obtained B.S. and M.S. from Peking University in 1991 and 1994, respectively, and Ph.D. in physics and optics from Oregon Center for Optics at the University of Oregon in 2000. Between 2000 and 2004, he was a project leader at 3M Company on fiber optics and photonic sensing devices for biomedical applications. In August of 2004, he joined the Department of Biological Engineering at the University of Missouri as an assistant professor. In January of 2010, he joined the Biomedical Engineering Department at the University of Michigan as an associate professor. In 2014, he was promoted to Professor.
Professor Fan’s research includes photonic bio/chemical sensors, micro/nano-fluidics, and nano-photonics for disease diagnostics and bio/chemical molecule analysis. In particular, he has 4 focuses: (1) Multi-dimensional micro-gas chromatography instrument development for vapor detection; (2) Optofluidic ELISA development for sensitive and rapid biomolecular analysis; (3) Optofluidic lasers; and (4) Study and development of novel optical and non-optical sensors. As of September 2016, he has approximately 130 peer-reviewed publications and over 20 issued/pending patents. Dr. Fan has served as Associate Editor for Optics Express, responsible for optical biological and chemical sensors and optofluidics. Presently, he serves on the Editorial Board for Lab on a Chip and Advisory Board of Advanced Materials Technologies. He has acted as a chair and organizer of numerous conferences for OSA, SPIE, Pittcon, IEEE, and MRS. He is a recipient of 3M Non-Tenured Faculty Award, American Chemical Society Petroleum Research Fund Award for Young Faculty, the Wallace H. Coulter Early Career Award (Phase I and Phase II), and the National Science Foundation CAREER Award. His research is supported by the National Science Foundation, National Institute of Health, private foundations, and industrial companies. He is Fellow of Optical Society of America and Royal Society of Chemistry.
Dr. Grotberg is currently a Professor in the Department of Biomedical Engineering and the Department of Surgery at the University of Michigan. He is also the Director of the University of Michigan - NASA Bioscience and Engineering Institute. He was an undergraduate at Cornell University in Biology, received his PhD in Fluid Mechanics at Johns Hopkins University, and then an MD from the University of Chicago. Following his internship year, he joined the faculty at Northwestern University from 1981 to 1998 jointly appointed in the Department of Biomedical Engineering and the Department of Anesthesiology. During that period he practiced Emergency Medicine in the Chicago and downstate Illinois regions. In 1998 he joined the University of Michigan.
Dr. Grotberg’s research focuses on biofluid dynamics and biotransport, primarily in the respiratory system. These include experimental and theoretical investigations of surfactant replacement therapy, aerosol delivery into the lung, microgravity ventilation, airway closure and reopening, flow induced oscillations such as wheezing and its relation to flow limitation, obstructive sleep apnea, liquid ventilation, high frequency ventilation, and implantable artificial lungs. In addition with colleagues he has collaborated to develop “Lung-on-a-Chip” microfluidics technology for testing pulmonary cells in controlled mechanical and chemical challenges. His work has been funded by NIH, NSF, NASA, NATO, BSF (Israel-US), ANR (France), The Coulter Foundation, The Whitaker Foundation, and industry.
Dr. Grotberg is a member of the select US National Committee on Biomechanics, a Fellow of the American Physical Society's Division of Fluid Dynamics, a Fellow of the American Institute for Medical and Biological Engineering, an Inaugural Fellow of the Biomedical Engineering Society, and a Fellow of the American Society of Mechanical Engineers. The latter cited him as “the leading Biofluid Dynamicist in the United States and among the top two or three in the world.”
Dr. Grotberg is an Associate Editor of Annual Review of Fluid Mechanics and Biophysical Journal, and a previous Associate Editor of Physics of Fluids and Journal of Biomechanical Engineering. He was the Kenan Distinguished Professor at Princeton University (2009) and holds visiting appointments in the Department of Physics at Ecole Polytechnique and the Department of Applied Mathematics at Ecole Normale Superieure de Cachan in Paris, France. During the course of his research and teaching, Dr. Grotberg has given 91 keynote and invited lectures, published 127 refereed journal articles, 14 book chapters, 253 proceedings and abstracts, and has an H-index of 28. He has accomplished this while mentoring 60 trainees, 28 of whom have gone on to become professors of medicine, engineering, mathematics and physics around the world.
Dr. Grotberg is active in the Detroit inner urban community with minority youth groups.
Dr. Khaing Oo received his B.S. (Hons) from Yangon University, M.S. from National University of Singapore, and Ph.D. from Stevens Institute of Technology in 2010. His research activities include sensors and sensing systems for healthcare solutions, especially in ultra-sensitive detection and identification of biochemical molecules in aqueous or vapor phase, development of rapid and sensitive point-of-care diagnostic devices (e.g., Optofluidic ELISA), high resolution hyper-spectral imaging using advanced functional materials and photonic crystal fiber, nanotechnology-enabled Surface-enhanced Raman Scattering (SERS), targeted drug delivery, and enhanced generation of reactive species during Photodynamic Therapy of cancer to improve specific cancer treatment. In addition, he has professional experience in computer aided design and engineering, and project management. He served as a reviewer for peer-reviewed journals in the areas of optical bio/chemical sensors and nanotechnology.
Mary-Ann Mycek, Ph.D., is a Professor in the Biomedical Engineering Department in the College of Engineering & the Medical School, a Faculty Member in the Applied Physics Graduate Program, and a Core Member of the Comprehensive Cancer Center at the University of Michigan.
After receiving her Ph.D. degree in Physics from the University of California, Berkeley, she conducted her postdoctoral training in laser medicine at the Wellman Laboratories of Photomedicine (Massachusetts General Hospital & Harvard Medical School), and accepted her first faculty appointment in the Physics & Astronomy Department at Dartmouth College.
Later, she joined the faculty of the University of Michigan’s BME Department and established the Biomedical Photonics Laboratory, where her translational research program seeks to impact patient care by creating non- and minimally-invasive optical diagnostic technologies.
At the University of Michigan, she has served twice as an Associate Chair for the BME Department: once as the Director of BME Graduate Programs and currently as the Associate Chair for Translational Research. Recent honors include election to the College of Fellows of the American Institute for Medical and Biological Engineering and to the Executive Board of the Rackham Graduate School at the University of Michigan.
Dr. Andrew Putnam is an associate professor in the Department of Biomedical Engineering, with a joint appointment in the Department of Chemical Engineering, at the University of Michigan. He obtained his B.S. in chemical engineering from UCLA in 1994, followed by a short stint at Amgen, one of the world’s largest biotechnology companies. His M.S.E. (1996) and Ph.D. (2001) degrees were earned in chemical engineering from the University of Michigan. Following post-doctoral training in cell biology, Dr. Putnam joined the faculty at the University of California, Irvine in January 2003, where he remained until becoming a UM faculty member in 2009.
Dr. Putnam’s area of expertise is the extracellular matrix (ECM), with a particular emphasis on the role of the ECM in regenerative therapies. Fundamental biological research in his laboratory addresses how the mechano-chemical properties of the ECM influence both normal and pathologic tissue morphogenesis, with an effort to define the mechanisms that drive these processes in 3D. He and his team then seek to leverage this fundamental knowledge to inspire the design of instructive biomaterials for applications in regenerative medicine, and as model systems in which to study disease. Dr. Putnam’s research involves a variety of hydrogel platforms, made from both natural (e.g., fibrin, collagen) and synthetic [e.g., poly(ethylene glycol)] polymers, and cell types (e.g., endothelial cells, mesenchymal stem cells, fibroblasts, smooth muscle cells, etc.). In recent years, they have focused most of their attention on cell/ECM-based strategies to direct vascularization in vitro and in vivo, with an eye towards developing new therapies for ischemic conditions in the clinic.
Over the years, Dr. Putnam’s research has been funded by the National Institutes of Health (NHLBI and NIDCR), National Science Foundation, California Institute for Regenerative Medicine, American Heart Association, and other foundations. He is a recipient of the NSF CAREER Award (2007) and a New Faculty Award from CIRM (2008), and plays an active role in the teaching mission of the Department of Biomedical Engineering.
After received his PhD degree at Purdue Univ. in 1991, Dr. Shih worked at Cummins Inc. at Columbus, Indiana as a manufacturing engineer to develop precision machining processes for a wide variety of diesel engines and fuel systems applications. From 1998 to 2002, he was Associate Professor in the Department of Mechanical and Aerospace Engineering, North Carolina State University. He joined University of Michigan (U-M) in 2003. Dr. Shih’s research and teaching focus are in design and manufacturing, particularly in medical devices. His research group has build knowledge base in bio-heat transfer, bio-impedance, ultrasound diagnosis, clinical simulators, and tissue cutting mechanics. He is a member of the renowned SM Wu Manufacturing Research Center (WuMRC) http://wumrc.engin.umich.edu. A key research thrust of WuMRC is the Biomedical Design and Manufacturing Lab (BDML) which works broadly in the innovative design and manufacturing technology to advance medical devices, healthcare operations, and patient safety.
Professor Shih is the co-founder of the Medical Innovation Center (MIC) and Fellow of ASME and SME. He is the recipient of the 1999 ASME BOSS Award, 2000 NSF CAREER Award, 2004 SAE Ralph Teetor Education Award, 2009 Fulbright Scholar, 2010 U-M Rackham Faculty Recognition Award, and 2011 U-M College of Engineering Research Award.
Dr. Takayama is Professor and Associate Chair for Technology Transfer in the Department of Biomedical Engineering at the University of Michigan. He also has an appointment in the Macromolecular Science and Engineering Program and currently serves on the executive committee of the Biointerfaces Institute, a multidisciplinary program between the School of Medicine and Dentistry and the Colleges of Pharmacy and Engineering at UM. He received his PhD from the Scripps Research Institute in 1998 and was a Leukemia and Lymphoma Society Postdoctoral Fellow at Harvard University from 1998-2000. He joined the University of Michigan in fall 2000.
His current technological research interests include microfluidics, nanofluidics, aqueous two phase systems, fracture fabrication, and microscale tissue engineering. The technologies are used to construct in vitro cell and tissue culture systems the recreate human physiology as well as to perform biochemical analyses. Examples of microfluidic models of the body constructed include micro-engineered models of lung injury, artificial oviducts for enhanced in vitro fertilization treatment, and 3D models of cancer metastasis. Examples of bioanalysis applications include crosstalk free multiplexed immunoassays for diagnosis of graft-versus-host-disease, multi-color histone modification mapping from single chromatin strands using nanofluidics, and dissecting G-protein coupled receptor signaling pathways through biochemical phase locking analysis. Dr. Takayama’s work has been funded by the NIH (NCI, NIGMS, NHGRI, NHLBI, NIBIB, NICHD), NSF (BES, DMI, CMMI, DBI, IIP), DTRA, Army, and others.
Dr. Takayama serves on the editorial board of the journals Microfluidics and Nanofluidics and Journal of Mechanics in Medicine and Biology and reviews for numerous journals in the micro/nanotechnology, materials science, physical sciences, and biology. He has published over 150 peer-reviewed articles. He is a standing member of the Instrumentation and Systems Development (ISD) Study Section at the Center for Scientific Review within the NIH and routinely assists with grant reviews in the area of instrumentation development. Dr. Takayama is also prolific inventor and has been recognized as the advisor of a Collegiate Inventor’s Award in Microfluidics from the National Inventors Hall of Fame & US Patent and Trademark Office. Other honors include The Ralph E. Powe Junior Faculty Award, NSF Career Award, College of Eng, George J Huebner, Jr Research Excellence Award, and 3Rs Highly Commended Award.