richard f. keep, phd

Professor, Neurosurgery
Professor,  Molecular and Integrative Physiology

734-764-5128

rkeep@umich.edu

Dr. Keep’s research interests are the blood-brain barriers and mechanisms of brain injury. The latter focuses on stroke (intracerebral hemorrhage, subarachnoid hemorrhage, intraventricular hemorrhage, cerebral ischemia) and traumatic brain injury. He primarily uses in vivo models (rat, mouse, pig), but also studies in vitro systems. His studies on the blood-brain and blood-CSF barriers spans normal physiology, the effects of disease states and the development of brain penetrant therapeutic agents. The latter currently includes developing therapeutic agents for lysosomal storage disorders, pain and neurotropic viruses. The blood-brain barrier studies also span in vitro and in vivo systems.

Dr. Keep did his undergraduate education at Cambridge University (England) and Ph.D at the University of Aberdeen. After postdoctoral fellowships at the University of Hull and King's College London, he joined the faculty in the Department of Neurosurgery in 1989. He is currently the Crosby Kahn Collegiate Professor of Neurosurgery, Director of the Crosby Neurosurgical Laboratories and Associate Chair for Research.