Weil Institute Visiting Scholar Seminar - “Crisis Breeds Innovation - How the COVID-19 Pandemic Invigorated Acute Care Clinical Trials”
WHO
Michael Puskarich, MD
(Associate Professor and Director of Research, Department of Emergency Medicine, University of Minnesota and Hennepin County Medical Center)
WHEN
February 3, 2023 | 10:00 - 11:00 AM
WHERE
North Campus Research Complex Building 10, South Atrium
LUNCH WILL BE PROVIDED
About the Speaker
Michael Puskarich, MD, MSCR
Associate Professor of Emergency Medicine, University of Minnesota
Dr. Puskarich is a practicing emergency physician and acute care clinical trialist who has been on the leading edge of COVID clinical trials since the onset of the pandemic.
He rapidly launched two multicenter trials in both the inpatient and outpatient settings repurposing losartan to modulate RAAS, opening to enrollment in April 2020 and completed within the first year of the pandemic. With University of Michigan investigators, he submitted one of the earliest platform trial proposals to the NIH in the spring of 2020. Building on his outpatient trial, he assisted University of Minnesota COVID-OUT investigators in completion of a decentralized factorial trial of repurposed putative outpatient treatments.
Dr. Puskarich has held various investigator and leadership roles in the REMAP-CAP RAAS domain, ACTIV-4a, ACTIV-4b, ACTIV-4d, C3PO, the CDC-RECOVER surveillance network, and currently serves in Hennepin international coordinating center leadership within the STRIVE network.
With a ground-level real-time perspective, he will discuss the accelerating effect the pandemic had on acute care clinical trial design and conduct using examples from the past 3 years, including operational advances in hands-off teleresearch and decentralized trials, navigation of ethical, regulatory, and public relations challenges, effects of network consolidation, increasing prevalence of adaptive and platform trials, and the statistical approaches and reporting helping push the acute care clinical trial literature forward.