Despite major advances in modern civilian medicine, few have been made that have specific impact in combat casualty care to improve long-term survival and recovery of the severely wounded warrior. The complexity and severity of wounds incurred on the battlefield are beyond what we experience at home. The delivery of care is also significantly complicated on the battlefield due to issues with terrain, transport availability, weather, and active combat conditions. These unique conditions make it imperative that researchers work to improve field treatment capability and make sophisticated life-saving care readily available to the injured, despite their location.

Thanks to the tireless efforts of MCIRCC research teams, the future of combat casualty care is looking bright. Over the past six months alone, MCIRCC has had 13 Department of Defense grants in the works—8 of which have already been submitted. These submissions are made possible thought the combination of MCIRCC’s cores: the Proposal Development Unit, Commercialization Coaching, the Pre-Clinical Critical Care Lab, the Data Science Team, the Clinical Research Unit, and Special Events.

DoD Peer Reviewed Medical Research Program – Technology/Therapeutic Development Award (will be submitted July 2019)

  • Katsuo Kurabayashi and team: An Ultra-high-­Performance Biomarker Analysis Platform for Personalized Treatment of Trauma-­Induced Acute Lung Injury (~$4.5M for 3 years)

  • David Machado-Aranda and team: Portable Non-Viral Gene Therapy Platform for the Treatment of Traumatic Lung Injury and Multidrug Resistant Pneumonia (~$4.5M for 3 years)

  • Lolo Eniola-Adefeso and team: Polyaspirin Particles as a Novel Treatment for Acute Lung Injury via Blocking of Excessive Neutrophil Lung Migration (~$4.5M for 3 years)

DoD Military Burn Research Program – Idea Development Award (will be submitted July 2019)

  • Anish Tuteja and team: Low Adhesion Wound Dressings with Rapid and Sustained Antimicrobial Performance (~$500K for 1.5 years)

DoD Peer Reviewed Medical Research Program – Focused Program Award (will be submitted July 2019)

  • Kayvan Najarian and team: A Focused Program to Improve Diagnosis and Advanced Therapy Prediction for ALI/ARDS Using Computational Modeling (~$11M for 4 years)

DoD Defense Medical Research and Development Program – Multi-Domain Lifesaving Trauma Innovations (submitted May 2019)

  • Kenn Oldham and team: Vascular Tone Monitoring for Improved Assessment, Triage, and Resuscitation During Prolonged Field Care (~$2.5M for 3 years)

  • Lena Napolitano and team: Algorithms to Predict Onset of Sepsis and Deterioration for Casualty and Surgical Patients in the Battlefield (~$1M for 2 years)

  • Katsuo Kurabayashi and team: A Battlefield-Deployable, Blood-Biomarker-Based Precision Medicine Platform for Post-Injury Sepsis and Organ Failure (~$2.5M for 3 years)

  • Kevin Ward/Hakam Tiba (subcontract): Pharmacologic Allosteric Hemoglobin Modification for Enhanced Delivery of Oxygen and Nitric Oxide (~$600K for 2 years)

DoD Peer Reviewed Medical Research Program – Discovery Award (submitted April 2019)

  • Rodney Daniels and team: Deployable Point-of-Care (POC) Blood Health Profile Utilizing Redox Potential Analysis and Red Cell Deformability Testing (~$200K for 2 years)

DoD United States Army Medical Research and Development Command – Broad Agency Announcement (submitted January 2019)

  • Kevin Ward and team: Hemodynamic Episode Likelihood Monitoring for Traumatic Injury (HELM) (~$3M for 2 years)

DoD Defense Medical Research and Development Program – Accelerating Innovation in Military Medicine (submitted January 2019)

  • Katsuo Kurabayashi and team: A Battlefield-Deployable Blood Biomarker Analysis Platform for Post-Injury Sepsis (~$500K for 1.5 years)

  • Rodney Daniels and team: Deployable Oxidation-Reduction Analysis Platform to Measure Oxidative Stress as a Biomarker for Shock and Therapeutic Response in Traumatic Injury and Sepsis (~$500K for 1.5 years)

From Bench to Battlefield—and Beyond

MCIRCC’s research and product portfolio is guided by the complexity of battlefield injuries, the challenges faced by first responders, and the echelons of care the wounded travel through before they reach a definitive trauma center. This integrative research plays a significant role in developing strategies that will not only be effectively deployed on the battlefield to save lives, but also those that will become next generation products and services here at home.