Large Animal Intensive Care Unit
Advanced Models for Pre-Clinical Translational Sciences
Our Pre-Clinical Operative and Intensive Care Unit Facility is a unique unit that produces best in class high-fidelity large animal models of multisystem trauma, cardiac arrest, sepsis, ARDS and traumatic brain injury allowing for combinatorial discovery and translational science as well as technology development. The unit is equipped with state of the art high resolution physiologic and metabolic monitoring and analytic equipment providing for unique “physiomic” monitoring, tissue banking and analysis for preclinical research.
The unit is equipped and staffed to serve as a fully functional operating room and intensive care unit. As such, the depth and breadth of critical illness and injury that can be explored may perhaps have few if any peers around the world. Work performed in MCIRCC’s Operative and Intensive Care Unit Facility has been critical in collecting advanced physiologic data as well as therapeutic, device, and diagnostic prototype data to support NIH, NSF, DoD, industry and internal funding opportunities for both preclinical and clinical translational opportunities. This also includes data used to support the transition of technology to Phase I clinical trials for therapeutics, and human trials for regulated use of class I and II devices.
The unit works in close collaboration with MCIRCC’s PDU, Big Data Platform Unit, Pre-Clinical Trials Unit and its Grand Challenge Unit to speed the development and transition of findings and technology to the bedside and to enhance opportunities for follow-on funding. Many of these are highlighted in the various appendices.
This unit has been extremely successful and in many cases transformative in
- Enhancing the medicine engineering-data science collaborative for development of next generation device, diagnostics, therapeutics, and digital health platforms.
- Designing IACUC approved protocols to allow augmented extraction of data and opportunities from these intense animal models to maximize opportunities.
Recent examples include trauma, TBI, vascular disease and cardiac arrest experiments designed to understand physiology that were also used to develop a new generation of coagulation and oxidative stress monitoring technologies, new cerebral monitoring technologies, new mathematical modeling methods for systems biology, and samples collected to discover new metabolomics and microbiome profiles produced by critical illness and injury.
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