We Drive Groundbreaking Critical Care Research


We Drive Groundbreaking Critical Care Research

Our Passion:

We want to shine the light on critical care so that we can find new and innovative ways to monitor, diagnose and treat critically ill and injured patients.

Critical illness and injury is the silent epidemic that affects more than 5.7 million Americans every year. It has an enormous societal and economic toll, yet it is not well understood by many.


Research Areas

Our research spans the major areas of critical care for maximum impact

Research Areas

Our research spans the major areas of critical care for maximum impact



Acute neurologic injuries in the brain and spinal cord are among the hardest injuries to treat. Each year in the United States, an estimated 1.7 million people sustain a traumatic brain injury, 795,000 suffer a stroke and 17,000 sustain a spinal cord injury. That’s why we’re developing diagnostics, monitors and therapeutics for patients who suffer acute neurologic catastrophes such as traumatic brain injury, hemorrhagic stroke, and acute spinal cord injury.



Sepsis is a severe inflammatory response to infection that can lead to multiple organ failure, resulting in permanent disability or death. Affecting more than one million patients a year, sepsis is one of the top 10 causes of death in the United States. Our research aims to enhance the pathophysiologic understanding of inflammation to develop new technologies for ultra-early diagnosis and therapeutic guidance.

CRITICAL heart conditions


Each year in the United States, approximately 325,000 sudden cardiac arrests occur outside the hospital, with a survival rate of only 12%. Our comprehensive approach to understanding the pathophysiology of cardiac arrest and cardiogenic shock guides our development of next generation diagnostic tools and therapeutics.



Trauma is the leading cause of death in the U.S. between the ages of 1 and 46, accounting for 41 million ER visits each year. On the battlefield, approximately 80% of all deaths occur within the first 30 minutes of wounding. Several important medical and surgical innovations created for military conflicts have found their way into everyday emergency and critical care practice. Research done at MCIRCC plays a significant role in developing technologies that will be used to save lives both on the battlefield and here at home. 


Critical Care Life Support


Each year, more people die from critical illness or injury than cancer or heart disease. It is the silent epidemic of our country that poses a huge cost to patients, families, and the healthcare system. While critical illness can impact every body part in a different way, many of our technologies and therapeutics can be adapted to improve outcomes for patients across the board.

Product Portfolio

Licensed and emerging critical care products

Product Portfolio

Licensed and emerging critical care products

Licensed Products

These products were licensed to industry partners through the combined efforts of our Commercialization Coach and the
University of Michigan Office of Tech Transfer.

Emerging Products

MCIRCC has a wide range of products that are ready to be licensed. Are you interested in licensing one of these projects?
Get in touch with us.

Education and Training

Mentoring the next generation of innovators

Education and Training

Mentoring the next generation of innovators


The University of Michigan offers a rich array of education and training programs related to critical illness and injury, supported by the National Institutes of Health. Many of MCIRCC's faculty members are also leaders in these programs and share common research and educational strategies and resources. 

The MCIRCC K12 Career Development Program in Emergency Critical Care Research

Thanks to NIH funding, MCIRCC offers a three-year, multidisciplinary training program in emergency critical care research. Scholars may choose mentoring teams led by nationally known senior clinician-scientists in Emergency Medicine, Pulmonary and Critical Care, Neurology, General and Trauma Surgery, Cardiovascular Disease, Biomedical Engineering, and Biostatistics. This gives trainees an understanding of all phases of emergency critical care research.

With the help of their mentoring team, scholars are able to design their three-year development plan including academic courses, professional development training, and research milestones. Through training in clinical trial design, grant writing, data management, and leadership, scholars will advance their research career with the goal of obtaining individual K or R01 funding by the end of their third year of K12 support.

MCIRCC Re-Imagining Critical Care Seminar Series

In keeping with MCIRCC's mission of transforming critical care through innovation, integration, and entrepreneurship, our Re-Imagining Critical Care seminar series is focused on combining the fundamentals of innovation with the tremendous opportunities that exist in critical care to improve outcomes. This series brings recognized University of Michigan faculty and other national experts in the fields of medicine, engineering, technology development, policy, and many others to discuss basic and advanced concepts in innovation and how these can be applied to recognize and fill the gaps that exist in critical care. Seminars are held once a month and open to the entire critical care, health science, engineering, data science, health policy, and innovation & entrepreneurship communities.  It is envisioned that these multidisciplinary seminars will lead to the creation of new ideas and teams to address challenges and identify solutions that will transform critical care science. Click the button below to see the complete line-up and find specific upcoming dates on the Events & Training page.

MCIRCC Visiting Scholar Seminar Series

Semi-annually, we invite leaders from all disciplines to present on a range of critical care topics such as neurologic catastrophes, sepsis and severe inflammation, trauma and combat casualty care, and cardiac emergencies. The MCIRCC Seminar Series provides a great opportunity for our members to network and discuss the latest in critical care medicine. Find upcoming speaker information on the Events & Training page. 

Past speakers include:

Leo Celi, MD, MS, MPH, Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center

Steffen Leonhardt, MD, PHD, Philips Endowed Chair of Medical Information Technology at the RWTH Aachen University

Todd E. Rasmussen, MD, FACS, Colonel USAF MC, Director, US Combat Casualty Care Research Program


In addition to offering MCIRCC's K12 training program in Emergency and Critical Care Research, we are proud to partner and collaborate with the following training and educational programs:


Training to Advance Care Through Implementation Science in Cardiac And Lung Illnesses (TACTICAL)


Scholars will be a mix of physicians, nurses, pharmacists, and PhDs with clinically relevant backgrounds. Model candidates will have just completed their clinical and initial research training, and will be ready to begin their first faculty position. In some cases, more mature practitioners who are changing the direction of their career toward independently funded research in implementation science will also be eligible. 

TACTICAL will provide five post-doctoral scholars a structured 3-year program of career development. Afterwards, as part of independent research careers focused on bringing evidence-based best practices to improve critically ill patients' lives, TACTICAL scholars will become independently-funded leaders who both drive change at their own institutions while also developing and evaluating better approaches for driving change nationally and internationally. 



Multidisciplinary T32 Research Training Program in Lung Disease


During the past several years, the scope of the program has been expanded to introduce trainees to new major areas of modern biology including genetics/genomics, metagenomics, proteomics, metabolomics, stem cell biology, computational biology, and the microbiome. Emerging fields of patient-oriented resaerch have been added or expanded, including health services research and sleep medicine. Our program is truly multidisciplinary, as more than 50 participating faculty trainers are drawn from six different divisions and 16 departments at the University. 

The NIH institutional training grant, Multidisciplinary Research Training Program in Lung Diseases (NHLBI T32HL007749), has been in existence since July 1, 1993. The initial program was directed by Galen B. Towes, MD, and supported research training for four post-graduate trainees. The program has been continuously funded since its inception and has provided research training for over 100 research scientists. Funding for the program supports training for 12 post-doctoral research fellows. While the program has evolved considerably over the past 20+ years, the foundations on which the program was built remain intact. 



Microfluidics in Biomedical Sciences Training Program

Although the program only supports six students, all those interested are invited to participate in activities sponsored by the program including the annual symposium, seminar series, PIBS 503, and core course CHE696. The program is designed to be an intellectually exciting blend of training in the more quantitative disciplines of chemistry, engineering, mathematics, and physics on the one hand, and the basic biological sciences on the other. 

The Microfluidics in Biomedical Sciences Training Program (MBSTP) is a National Institute of Health/National Institute of Biomedical Imaging and Bioengineering funding training program that supports and interdisciplinary approach to graduate training that emphasizes biomedical microfluidics. The program supports six students for two years each. 45 faculty members from 20 different departments from the College of Engineering, the College of LSA, and the Medical School participate.